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According to BetOnline.ag, Steelers running back Najee Harris has 16-1 odds to win Offensive Rookie of the Year in 2021. Harris has the seventh-best odds on the list and is tied with Texans quarterback Davis Mills, who was selected in the second round of the draft.
In front of Harris are the five quarterbacks who were selected in the first round of the draft, along with Bengals wide receiver Ja'Marr Chase, Falcons tight end Kyle Pitts and Eagles wide receiver DeVonta Smith, who was teammates with Harris at Alabama.
The last time a Steelers player won Rookie of the Year was Ben Roethlisberger in 2004 and the last running back to receive the award was Saquon Barkley of the Giants in 2018. Saints running back Alvin Kamara also won it in 2017 and Todd Gurley, formerly of the Rams, won the award in 2015. So there's a relatively good history of running backs winning Offensive Rookie of the Year in recent years.